HRID1188040
反应详情
EQUATION
反应方程式
REACTANTS
反应物
HCID674
Dimethylamine
C2H7N
HCID81531
Diisopropylethylamine
C8H19N
HCID9886157
Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
C10H15F6N6OP
HCID58180515
4-Thiazolecarboxylic acid, 2-[[7-[(dicyclopropylamino)carbonyl]-6-ethyl-1,6-dihydro-1-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-yl]amino]-
C22H23N7O3S
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
To 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)thiazole-4-carboxylic acid (example 12A, 44 mg, 0.095 mmol) in DMF (2 ml) was added HATU (108 mg, 0.284 mmol), DIPEA (0.066 mL, 0.378 mmol), and dimethylamine (0.013 mL, 0.189 mmol). The reaction was stirred at rt for 3 h, then the solvent was removed in vacuo. The residue was purified by preparative HPLC to give 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-4-ylamino)-N,N-dimethylthiazole-4-carboxamide (10 mg, 21% yield) as a brown solid.
WORKUP
后处理
- customthe solvent was removed in vacuo
- customThe residue was purified by preparative HPLC