Sodium Hydroxide → HCID 58180599, compound

Participants

Reaction Steps

To a solution of ethyl 2-(7-(dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)thiazole-5-carboxylate (example 19, 14.6 mg, 0.030 mmol) in EtOH (296 μL) was added 1 N NaOH aqueous solution (296 μL). The reaction mixture was stirred at rt 3 h and stirred at 50° C. 18 h. After cooling to room temperature, ethanol was removed by concentration in vacuo. The residue was acidified with 1 N HCl and the solid product was collected by filtration. 2-(7-(Dicyclopropylcarbamoyl)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-ylamino)thiazole-5-carboxylic acid was isolated as a pale yellow solid which was used crude in the next reaction.

Provenance & Evidence