Methanol → HCID 178497264, compound

Participants

Reaction Steps

5-p-Tolyl-1H-pyrazole-3-carboxylic acid (250 mg, 1.24 mmol) and sulfuric acid (120 μL, 1.48 mmol) in methanol (5 mL) were heated to reflux for 16 hrs. The solvent was evaporated and the residue was resuspended in CH2Cl2. The residue was filtrated and the filtrate was washed with water and brine and dried over Na2SO4. Solvent was evaporated and the white solid was combined with the precipitate collected previously. Methyl 5-p-tolyl-1H-pyrazole-3-carboxylate (224 mg, 84%) was obtained as a white solid. 1H-NMR (400 MHz, CDCl3): (ppm)=7.56 (d, J=7.6 Hz, 2H), 7.22 (d, J=8.0 Hz, 2H), 7.02 (s, 1H), 3.91 (s, 3H), 2.36 (s, 3H).

Provenance & Evidence