HCID 59408778, compound → HCID 59408762, compound

Participants

Reaction Steps

6-Bromo-N-(5-(5-bromopyridin-2-ylcarbamoyl)pyridin-2-yl)nicotinamide 6 (350 mg, 0.73 mmol) was dissolved in neat n-propylamine. The reaction mixture was heated for 3 days at reflux temperature. Then the solvent was evaporated to give a crude product, which was crystallized in EtOAc to give 6-(propylamino)-N-(5-(5-(propylamino)pyridin-2-ylcarbamoyl)pyridin-2-yl)nicotinamide 7 (122 mg, 38% yield) as a white solid. Mp. 249-250° C.

Provenance & Evidence