HCID 59408770, compound → HCID 59408767, compound

Participants

Reaction Conditions

Reaction Steps

N-(6-Bromopyridin-2-yl)-5-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxamide 3 (300 mg, 0.67 mmol) was dissolved in benzylamine (3 ml). The reaction mixture was heated for 24 hrs at 130° C. Then the reaction mixture was purified on a silica gel column (1:5 EtOAc:Pet-ether) to give N-(6-(benzylamino)pyridin-2-yl)-5-(4-fluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxamide 4 as a white solid (187 mg, 59%). Mp. 139-140° C.

Provenance & Evidence