HCID 59408770, compound → HCID 59408767, compound

Participants

Reaction Conditions

Reaction Steps

The 6-bromo-N-(5-(4-fluorophenyl)-1H-pyrazol-3-yl) picolinamide 3 (307 mg, 0.88 mmol) was dissolved in neat benzylamine (3 mL) without further characterization. The reaction mixture was heated at 130° C. for 24 hrs. Then the solvent was evaporated and the residue was purified on silica gel (EtOAc: pet-ether, 1:4) to give 6-(benzylamino)-N-(5-(thiophen-2-yl)-1H-pyrazol-3-yl)picolinamide 4 as a sticky solid (200 mg, 58%).

Provenance & Evidence