HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-N-Boc-Amino-Thiazole-5-Carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 2-((tert-butoxy(hydroxy)methylidene)amino)-1,3-thiazole-5-carboxylate | HCID 7213140 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 2-N-Boc-Amino-Thiazole-5-Carboxylic Acid | HCID 22271442 | 86% |
Reaction Steps
A solution of ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate (5 g, 18.36 mmol) and KOH (10.3 g, 184 mmol) in EtOH/H2O (1:1) (60 mL) was stirred at RT for 12 hrs. The solution was acidified with 1N HCl and the precipitate was filtered and dried, yielding 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid (3.84 g, 86%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673940B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-2c3b91c932b04c58a6838a42189969ca |
| Source note | uspto-grants-2014_03 |