Methanol → HCID 59408756, compound

Participants

Reaction Steps

Methanol (5 mL) and Pd/C were added to a solution of 5-nitro-1-(tetrahydro-2H-pyran-2-yl)-N-(1-(tetrahydro-2H-pyran-2-yl)-5-p-tolyl-1H-pyrazol-3-yl)-1H-pyrazole-3-carboxamide (183 mg, 0.38 mmol) in THF. The flask was then evacuated and filled with hydrogen. The reaction mixture was stirred for 16 hrs. The catalyst was filtered on celite and the solution was concentrated and dried to give 5-amino-1-(tetrahydro-2H-pyran-2-yl)-N-(1-(tetrahydro-2H-pyran-2-yl)-5-p-tolyl-1H-pyrazol-3-yl)-1H-pyrazole-3-carboxamide (170 mg, quantitative).

Provenance & Evidence