2-Amino-4-(4-chlorophenyl)thiazole → HCID 59408743, compound

HRID 1188149Notes

Reaction equation

HRID 1188149 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([NH2:13])[S:11][CH:12]=2)=[CH:4][CH:3]=1.Br[C:15]1[S:16][C:17]([C:20](O)=O)=[CH:18][N:19]=1>>[CH2:8]([NH:9][C:15]1[S:16][C:17]([CH2:20][NH:13][C:10]2[S:11][CH:12]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:9]=2)=[CH:18][N:19]=1)[C:5]1[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 732412-Amino-4-(4-chlorophenyl)thiazoleHCID 27632102-Bromothiazole-5-carboxylic acid

Product 1

HCID 59408743HCID 59408743, compound

Procedure

Compound 2ak was prepared as described for 2 h starting from 4-(4-chlorophenyl)thiazol-2-amine and 2-bromothiazole-5-carboxylic acid (31 mg, 49%). Mp. 105-106° C.

Workup

  1. customCompound 2ak was prepared

Sources & evidence

ORD record
ord-dab9caf0018d4156be7a2f2f610f1b32
Source dataset
uspto-grants-2014_03
Patent number
US08673940B2

Reaction notes

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