HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-(3,5-Difluorophenyl)-3-methoxy-1-methyl pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 3-(3,5-Difluorophenyl)-3-methoxypyrrolidine | HCID 19935874 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | 3-(3,5-Difluorophenyl)-3-methoxy-1-methyl pyrrolidine | HCID 46219224 | — |
Reaction Steps
Preparation according to Example 16. (−)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine (0.02 g, 0.094 mmol), formic acid (1 ml) and formaldehyde (40% solution in water, 1 ml) was heated at 85° C. for 5 h, workup according to preparation 16. MS m/z (relative intensity, 70 eV) 227 (M+, 5), 212 (32), 197 (28), 141 (45), 57 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673962B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-4b4e465cf41e4fa491eb6172a49988f7 |
| Source note | uspto-grants-2014_03 |