HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → 3-(3,4-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(3,4-Difluorophenyl)-3-methoxypyrrolidine | HCID 46219221 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3,4-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine | HCID 46219222 | — |
Reaction Steps
Preparation according to Example 22: (+)-3-(3,4-difluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.047 mmol), triethylamine (13.1 μL, 0.093 mmol), tetrahydrofuran (2 ml) and iodoethane (5.6 μL, 0.07 mmol). The crude product analyzed by GCMS. Analysis showed 92% conversion. MS m/z (relative intensity, 70 eV) 241 (M+, 6), 226 (46), 211 (23), 141 (43), 71 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673962B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-9079f78ee44045558743944310c2bb5e |
| Source note | uspto-grants-2014_03 |