HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 3-(3,4-Difluorophenyl)-3-methoxy-1-methylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | 3-(3,4-Difluorophenyl)-3-methoxypyrrolidine | HCID 46219221 | — |
| Solvent | Formaldehyde | HCID 712 | — |
| Product | 3-(3,4-Difluorophenyl)-3-methoxy-1-methylpyrrolidine | HCID 46219228 | — |
Reaction Steps
Preparation according to Example 25: (+)-3-(3,4-difluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.047 mmol) in formic acid (1 ml) and formaldehyde (37% solution in water, 1 ml). The crude product analyzed by GCMS. Analysis showed 87% conversion. MS m/z (relative intensity, 70 eV) 227 (M+, 3), 212 (17), 197 (18), 141 (36), 57 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673962B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-c9aceb155b774ba7b51f0b5782855eb8 |
| Source note | uspto-grants-2014_03 |