HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 3-(3,4-Difluorophenyl)-3-methoxy-1-methylpyrrolidine-1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 3-(3,4-Difluorophenyl)-3-methoxy-1-methylpyrrolidine | HCID 46219228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(3,4-Difluorophenyl)-3-methoxy-1-methylpyrrolidine-1-oxide | HCID 46219354 | — |
Reaction Steps
Preparation according to Example 32: Enantiomer 1 of 3-(3,4-difluorophenyl)-3-methoxy-1-methylpyrrolidine (0.009 g, 0.039 mmol), dichloromethane (2 ml), 3-chloroperoxybenzoic acid (77%) (0.018 g, 0.08 mmol). The crude product was analyzed by LCMS (Qtrap, Applied Biosystems, Q1 MS), analysis showed <95% conversion: MS (m+1)/z; 244 (M+1, bp), 243 (8), 214 (4), 197 (4), 142 (4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673962B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-c057e0a12343451c9e9b6ccc132e1218 |
| Source note | uspto-grants-2014_03 |