HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → 3-(3-Chloro-5-fluorophenyl)-1-ethyl-3-methoxypyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(3-Chloro-5-fluorophenyl)-3-methoxypyrrolidine | HCID 46219223 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3-Chloro-5-fluorophenyl)-1-ethyl-3-methoxypyrrolidine | HCID 46219357 | — |
Reaction Steps
Preparation according to Example 22. (−)-3-(3-chloro-5-fluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.043 mmol), triethylamine (12.1 μL, 0.086 mmol), tetrahydrofuran (2 ml) and iodoethane (5.2 μL, 0.065 mmol). The crude product analyzed by GCMS. Analysis showed 83% conversion. MS m/z (relative intensity, 70 eV) 257 (M+, 8), 242 (78), 227 (31), 157 (36), 71 (bp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673962B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-42be5b2fc7ce4569b54ea251b32ca35b |
| Source note | uspto-grants-2014_03 |