N-tert-Butoxycarbonyl-L-aspartic acid beta-benzyl ester → HCID 66874810, compound

HRID 1188228Notes

Reaction equation

HRID 1188228 reaction equation
[ClH:1].Cl.[CH2:3]([O:10][C:11](=[O:19])[CH2:12][C@@H:13]([NH2:18])[CH2:14][N:15]([CH3:17])[CH3:16])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(OC(=O)C[C@@H](C(O)=O)NC(OC(C)(C)C)=O)C1C=CC=CC=1>>[ClH:1].[ClH:1].[CH2:3]([O:10][C:11](=[O:19])[CH2:12][C@H:13]([NH2:18])[CH2:14][N:15]([CH3:16])[CH3:17])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 1581888N-tert-Butoxycarbonyl-L-aspartic acid beta-benzyl esterHCID 46223507(R)-benzyl 3-amino-4-(dimethylamino)butanoate dihydrochloride2×

Product 1

HCID 66874810HCID 66874810, compound

Procedure

(S)-3-Amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride was prepared in analogy with (R)-3-amino-4-dimethylamino-butyric acid benzyl ester dihydrochloride (intermediate 1), starting from Boc-L-aspartic acid 4-benzyl ester.

Sources & evidence

ORD record
ord-eadca96b69bf47f5a123de8886b87a22
Source dataset
uspto-grants-2014_03
Patent number
US08673946B2

Reaction notes

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