HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → Didesmethylsibutramine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| Product | Didesmethylsibutramine | HCID 134772 | 56.2% |
Reaction Steps
As described in article (Chinese Journal of Pharmaceuticals, 2001, 32(8): 337-339), p-chlorobenzyl cyanide was condensed with 1,3-dibromopropane, cycled to give cyclobutyl inter mediate, and then through Grignard reaction and reduction reaction to give title compound (56.2% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673981B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-4c024b522e8d4ebf9564bd9c02bfb49a |
| Source note | uspto-grants-2014_03 |