HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188334Generated: October 25, 2026
Cesium carbonate → 2-[4-Chloro-5-cyano-2-(difluoromethyl)-1H-indol-1-yl]propanamide
https://huagongshe.com/reaction/1188334
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromopropanamide | HCID 101118 | — |
| Reactant | 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile | HCID 24985632 | — |
| Product | 2-[4-Chloro-5-cyano-2-(difluoromethyl)-1H-indol-1-yl]propanamide | HCID 24985805 | — |
Reaction Steps
Synthesized as described in Example 4 using 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile, 2-bromo-propionamide (2 eq) and Cs2CO3 (2 eq). After heating at 90° C. for 4 h, additional 2-bromo-propionamide (2 eq) and Cs2CO3 (2 eq) were added and the reaction mixture heated at 110° C. for 15 h: MS (ES) m/z 298 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08673948B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-a29cdb4e6cd84f11928fc358f443b916 |
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| Source note | uspto-grants-2014_03 |
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