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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188349Generated: October 31, 2026

2-(Chloromethyl)-5-cyclopropyl-1,3,4-thiadiazole → 4-Chloro-1-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)methyl]-2-(difluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188349

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)-5-cyclopropyl-1,3,4-thiadiazoleHCID 2757679—
Reactant4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrileHCID 24985632—
Product4-Chloro-1-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)methyl]-2-(difluoromethyl)-1H-indole-5-carbonitrileHCID 24985971—

Reaction Steps

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 2-(chloromethyl)-5-cyclopropyl-1,3,4-thiadiazole: MS (ESI) m/z 365 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-0699d054fa6a457495c3c0a91af51aa2
Source noteuspto-grants-2014_03