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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188353Generated: October 26, 2026

3-(Chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole → 2-(Difluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-4,5-dicarbonitrile

https://huagongshe.com/reaction/1188353

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazoleHCID 2736622—
Reactant2-(difluoromethyl)-1H-indole-4,5-dicarbonitrileHCID 57800341—
Product2-(Difluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-4,5-dicarbonitrileHCID 24983678—

Reaction Steps

Synthesized as described in Example 23 from 2-(difluoromethyl)-1H-indole-4,5-dicarbonitrile and 3-(chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole: MS (ES) m/z 444 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-aa5dca963e284647b26cfc7d7406a2df
Source noteuspto-grants-2014_03