HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxylic acid → 1-({5-[3-Methyl-5-(trifluoromethyl)-4-isoxazolyl]-1,2,4-oxadiazol-3-yl}methyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methyl-5-(trifluoromethyl)-1,2-oxazole-4-carboxylic acid | HCID 2775645 | — |
| Reactant | HCID 178509476 | HCID 178509476 | — |
| Product | 1-({5-[3-Methyl-5-(trifluoromethyl)-4-isoxazolyl]-1,2,4-oxadiazol-3-yl}methyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 24984143 | — |
Reaction Steps
Synthesized as described in Example 72 from 2-[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide and 3-methyl-5-(trifluoromethyl)-4-isoxazolecarboxylic acid: MS (ESI): m/z 442 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673948B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-7021e65f7af54daf8e60cf4eec0347b8 |
| Source note | uspto-grants-2014_03 |