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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188405Generated: October 26, 2026

5-Bromonicotinohydrazide → 1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188405

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-BromonicotinohydrazideHCID 696365—
Reactant[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acidHCID 57800132—
Product1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 24984781—

Reaction Steps

Synthesized as described in Example 35C from [5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and 5-bromo-3-pyridinecarbohydrazide: MS (ES) m/z 448 and 450 (M+1 Br isotopes).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-785c623bc86545f1b2ff5094abb8968a
Source noteuspto-grants-2014_03