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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188406Generated: November 3, 2026

5-Bromofuran-2-carbohydrazide → 1-{[5-(5-Bromo-2-furanyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188406

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromofuran-2-carbohydrazideHCID 468636—
Reactant[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acidHCID 57800132—
Product1-{[5-(5-Bromo-2-furanyl)-1,3,4-oxadiazol-2-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 24984782—

Reaction Steps

Synthesized as described in Example 35C from [5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and 5-bromo-2-furancarbohydrazide: MS (ES) m/z 437 and 439 (M+1 Br isotopes).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-b4b349f2d72a45c4b37678a16cdb1ac6
Source noteuspto-grants-2014_03