[5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid → 1-({3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 1188440ノート

反応式

HRID 1188440 の反応式
[C:1]([C:3]1[C:4]([C:17]([F:20])([F:19])[F:18])=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13](O)=[O:14])[C:7]([CH3:16])=[CH:6]2)#[N:2].O[NH:22][C:23]([C:25]1[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[C:27]([C:35]([F:38])([F:37])[F:36])[CH:26]=1)=[NH:24]>>[F:32][C:31]([F:33])([F:34])[C:29]1[CH:30]=[C:25]([C:23]2[N:24]=[C:13]([CH2:12][N:8]3[C:9]4[C:5](=[C:4]([C:17]([F:18])([F:20])[F:19])[C:3]([C:1]#[N:2])=[CH:11][CH:10]=4)[CH:6]=[C:7]3[CH3:16])[O:14][N:22]=2)[CH:26]=[C:27]([C:35]([F:38])([F:37])[F:36])[CH:28]=1

参加物

3

反応物 2

HCID 67404858[5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]acetic acidHCID 178513327HCID 178513327、化合物

生成物 1

HCID 866206681-({3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

実験手順

Synthesized as described in Example 37 using [5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and N-hydroxy-3,5-bis(trifluoromethyl)benzenecarboximidamide: 1H NMR (400 MHz, CDCl3) δ 8.47 (s, 2H), 8.02 (s, 1H), 7.61 (m, 2H), 6.71 (s, 1H), 5.62 (s, 2H), 2.65 (s, 3H); MS (ES) m/z 519 (M+1).

後処理

  1. customSynthesized

出典と根拠

ORDレコード
ord-2478bbc867984f80b8af7507a2d609ec
出典データセット
uspto-grants-2014_03
特許番号
US08673948B2

反応ノート

読み込み中…