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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188451Generated: October 26, 2026

3-(Chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole → 3-Fluoro-2-methyl-4-(trifluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188451

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazoleHCID 2736622—
Reactant3-fluoro-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57800310—
Product3-Fluoro-2-methyl-4-(trifluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrileHCID 57800521—

Reaction Steps

Synthesized as described in Example 23 from 3-fluoro-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole: MS (ES) m/z 469 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-26c74e02437346fa823f09e0e9f15ab9
Source noteuspto-grants-2014_03