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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188452Generated: October 26, 2026

3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-3-fluoro-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188452

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazoleHCID 43120209—
Reactant3-fluoro-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57800310—
Product1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-3-fluoro-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57800512—

Reaction Steps

Synthesized as described in Example 23 from 3-fluoro-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole: MS (ES) m/z 437 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-74091ef8307f4b72b47aed1ece79ff23
Source noteuspto-grants-2014_03