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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188455Generated: October 25, 2026

Cesium carbonate → Methyl 2-[5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]propanoate

https://huagongshe.com/reaction/1188455

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCesium carbonateHCID 10796—
ReactantMethyl 2-bromopropionateHCID 95576—
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
ProductMethyl 2-[5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]propanoateHCID 57800182—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile, methyl 2-bromopropanoate (1.5 eq) and Cs2CO3 (1.5 eq): MS (ES) m/z 311 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-0ade7fd29a2c4f2884fdce72b30045fb
Source noteuspto-grants-2014_03