HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188459Generated: November 4, 2026
2-Bromoacetamide → 2-[5-Cyano-2-ethyl-4-(trifluoromethyl)-1H-indol-1-yl]acetamide
https://huagongshe.com/reaction/1188459
Participants
| Role | Name | HCID | Charge |
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| Reactant | 2-Bromoacetamide | HCID 69632 | — |
| Reactant | 2-ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67403819 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-[5-Cyano-2-ethyl-4-(trifluoromethyl)-1H-indol-1-yl]acetamide | HCID 67406116 | 376.3% |
Reaction Steps
2-Ethyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (0.004 g, 0.018 mmol) Cs2CO3 (0.051 g, 0.16 mmol), and 2-bromoacetamide (0.022 g, 0.16 mmol) were combined in CH3CN (3 mL) and heated at 90° C. under N2 for 1 hr. Extraction with Et2O and washing with water and brine was followed by drying (Na2SO4), filtration, and concentration in vacuo. Purification (SiO2, EtOAc/hexanes) afforded the title compound (0.020 g): MS (ESI): m/z 296 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08673948B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-3149bc879a534d679bab611f2e729f73 |
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| Source note | uspto-grants-2014_03 |
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