2-Bromoacetamide → HCID 67405481, compound

HRID 1188477Notes

Reaction equation

HRID 1188477 reaction equation
[CH:1]1([C:4]2[NH:5][C:6]3[C:11]([CH:12]=2)=[C:10]([C:13]([F:16])([F:15])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=3)[CH2:3][CH2:2]1.Br[CH2:20][C:21]([NH2:23])=[O:22]>>[C:17]([C:9]1[C:10]([C:13]([F:14])([F:15])[F:16])=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]([CH2:20][C:21]([NH2:23])=[O:22])[C:4]([CH:1]1[CH2:2][CH2:3]1)=[CH:12]2)#[N:18]

Participants

3

Reactant 2

HCID 696322-BromoacetamideHCID 674044722-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 67405481HCID 67405481, compound

Procedure

Synthesized as described in Example 4 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 2-bromoacetamide: 1H NMR (400 MHz, DMSO-d6) δ 7.82 (d, J=8.4 Hz, 1H), 7.71 (bs, 1H), 7.67 (d, J=8.4 Hz, 1H), 7.35 (bs, 1H), 6.37 (s, 1H), 5.02 (s, 2H), 1.94 (m, 1H), 0.99 (m, 2H), 0.77 (m, 2H); MS (ES) m/z 308 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-4a368ab1f3f7418cb2b71508df2a2ab0
Source dataset
uspto-grants-2014_03
Patent number
US08673948B2

Reaction notes

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