2-Bromoacetamide → 2-[5-Cyano-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indol-1-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-Bromoacetamide	HCID 69632	—
Reactant	2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile	HCID 67405196	—
Product	2-[5-Cyano-2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indol-1-yl]acetamide	HCID 67406216	—

Reaction Steps

Synthesized as described in Example 4 using 2-(2-methylpropyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile and 2-bromoacetamide: 1H NMR (400 MHz, DMSO-d6) δ 7.82 (d, J=8.5 Hz, 1H), 7.71 (bs, 1H), 7.67 (d, J=8.5 Hz, 1H), 7.34 (bs, 1H), 6.51 (d, J=2.2 Hz, 1H), 4.91 (s, 2H), 2.61 (d, J=7.0 Hz, 2H), 1.95 (m, 1H), 0.92 (d, J=6.6 Hz, 6H); MS (ES) m/z 324 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673948B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-d61b579f6f6f4ccb9d4fc897ab5b9079
Source note	uspto-grants-2014_03