3-(Chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole → 2-Propyl-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-4,5-dicarbonitrile

Participants

Role	Name	HCID	Charge
Reactant	3-(Chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole	HCID 2736622	—
Reactant	2-propyl-1H-indole-4,5-dicarbonitrile	HCID 57800367	—
Product	2-Propyl-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-4,5-dicarbonitrile	HCID 57800240	—

Reaction Steps

Synthesized as described in Example 4 from 2-propyl-1H-indole-4,5-dicarbonitrile and 3-(chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 8.30 (d, J=7.6 Hz, 1H), 8.25 (s, 1H), 8.14 (s, 1H), 8.07 (d, J=7.6 Hz, 1H), 7.90-7.80 (m, 2H), 7.70 (d, J=8.4 Hz, 1H), 5.95 (s, 2H), 3.06 (t, 2H), 1.79-1.67 (m, 2H), 0.95 (t, J=7.2 Hz, 3H); MS (ES) m/z 436 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673948B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-34fe45259b4f406aa2f24c2b03f5bcb8
Source note	uspto-grants-2014_03