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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188566Generated: November 3, 2026

3-Chloro-2,6-difluorobenzoic acid → 1-{[5-(3-Chloro-2,6-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188566

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Chloro-2,6-difluorobenzoic acidHCID 2773534—
ReactantHCID 178509476HCID 178509476—
Product1-{[5-(3-Chloro-2,6-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57800431—

Reaction Steps

Synthesized as described in Example 241 from 2-[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide and 3-chloro-2,6-difluorobenzoic acid: MS (APCI) m/z 440 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-ae69c58890e6475cbad1cb7fbea58422
Source noteuspto-grants-2014_03