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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188573Generated: October 25, 2026

5-(Chloromethyl)-3-phenylisoxazole → 1-[(3-Phenyl-5-isoxazolyl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188573

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Chloromethyl)-3-phenylisoxazoleHCID 2764057—
Reactant4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405449—
Product1-[(3-Phenyl-5-isoxazolyl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405206—

Reaction Steps

Synthesized in a manner similar to Example 23 using 4-(trifluoromethyl)-1H-indole-5-carbonitrile and 5-(chloromethyl)-3-phenylisoxazole: MS (ES) m/z 368 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-9e63ba42a55a401ba297ad25ee7604d8
Source noteuspto-grants-2014_03