Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | (5-Bromofuran-2-yl)methanol | HCID 14595701 | — |
| Product | Triphenylphosphine | HCID 11776 | — |
| Product | 2-Bromo-5-(chloromethyl)furan | HCID 12207891 | — |
Reaction Steps
To a solution of (5-bromo-2-furanyl)methanol (Example 310A) (144 mmol) in dry carbon tetrachloride (30 mL) was added triphenylphosphine (6.0 g, 228 mmol) at rt. The reaction is heated at 75° C. for 1 h. Concentration and purification by radial chromatography (0-10% EtOAc-hexanes gradient) afforded the title compound with contamination of triphenylphosphine. The product is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08673948B2 |
|---|
| Source dataset | uspto-grants-2014_03 |
|---|
| ORD ID | ord-5493467e1eff4d18ae05606b3ad97681 |
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| Source note | uspto-grants-2014_03 |
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