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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188625Generated: October 26, 2026

2-Bromo-5-(chloromethyl)furan → 1-[(5-Bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188625

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-5-(chloromethyl)furanHCID 12207891—
Reactant2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404472—
Product1-[(5-Bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404993—

Reaction Steps

Synthesized as described in Example 4 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 165A) and 2-bromo-5-(chloromethyl)furan (Example 310B): MS (ES) m/z 409 (M+1) and 411 (M+1, isotope).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-dbb1f23a19274c9faf51febd2cd5f8dc
Source noteuspto-grants-2014_03