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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188633Generated: November 2, 2026

(3,5-Difluorophenyl)boronic acid → 1-{[5-(3,5-Difluorophenyl)-2-thienyl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188633

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3,5-Difluorophenyl)boronic acidHCID 2734338—
ReactantHCID 67404974HCID 67404974—
Product1-{[5-(3,5-Difluorophenyl)-2-thienyl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67403714—

Reaction Steps

Synthesized as described in Example 310D using 1-[(5-bromo-2-thienyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 314B) and [3,5-difluorophenyl]boronic acid: MS (ES) m/z 431 (M−1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-006c0568de8f43aa969598e15003a0bd
Source noteuspto-grants-2014_03