Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188641Generated: November 1, 2026

2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → HCID 86620705, compound

https://huagongshe.com/reaction/1188641

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
ReactantHCID 57800482HCID 57800482—
ProductHCID 86620705HCID 86620705—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 2-[3,5-bis(trifluoromethyl)phenyl]-5-(chloromethyl)-1,3-thiazole (Example 321B): 1H NMR (400 MHz, CDCl3) δ 8.26 (s, 2H), 7.89 (s, 1H), 7.74 (s, 1H), 7.57 (d, J=8.5 Hz, 1H), 7.53 (d, J=8.5 Hz, 1H), 6.67 (s, 1H), 5.58 (s, 2H), 2.57 (s, 3H): MS (ES) m/z 532 (M−1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-090ac58f403b43cf8cc58df2c02d519d
Source noteuspto-grants-2014_03