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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188657Generated: November 1, 2026

2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → HCID 67406398, compound

https://huagongshe.com/reaction/1188657

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
ReactantHCID 67404843HCID 67404843—
ProductHCID 67406398HCID 67406398—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 2-bromoethyl-4-fluorophenylether: 1H NMR (400 MHz, CDCl3) δ 7.57 (d, J=8.5 Hz, 1H), 7.52 (d, J=8.5 Hz, 1H), 6.92 (t, J=8.6 Hz, 2H), 6.69 (m, 2H), 6.59 (s, 1H), 4.53 (t, J=5.3 Hz, 2H), 4.20 (t, J=5.3 Hz, 2H), 2.57 (s, 3H): MS (ES) m/z 363 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-1c0b9e83faa84c7dbc28a285648d04e3
Source noteuspto-grants-2014_03