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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188658Generated: November 1, 2026

1-[(1R)-2-Hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → 2-Methyl-1-[(1R)-1-methyl-2-(2-pyridinyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188658

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[(1R)-2-Hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404820—
ReactantHCID 178516071HCID 178516071—
Product2-Methyl-1-[(1R)-1-methyl-2-(2-pyridinyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67407301—

Reaction Steps

Synthesized as described in Example 139C using 1-[(1R)-2-hydroxy-1-methylethyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 329) and 2-pyridinol: MS (ES) m/z 360 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-e07cfa7032914103a37b73d5041b7825
Source noteuspto-grants-2014_03