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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188663Generated: November 2, 2026

1-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → 2-Methyl-1-[2-(2-pyridinyloxy)propyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188663

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67403809—
ReactantHCID 178516071HCID 178516071—
Product2-Methyl-1-[2-(2-pyridinyloxy)propyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67406632—

Reaction Steps

Synthesized as described in Example 139C using 1-(2-hydroxypropyl)-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 335) and 2-pyridinol: MS (ES) m/z 360 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-75ec7dd2b22c425cb1ceac3099da7133
Source noteuspto-grants-2014_03