2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile → HCID 86620711, compound

HRID 1188665Notes

Reaction equation

HRID 1188665 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.Br[CH2:18][CH2:19][O:20][C:21]1[CH:22]=[CH:23][C:24]([Cl:27])=[N:25][CH:26]=1>>[Cl:27][C:24]1[N:25]=[CH:26][C:21]([O:20][CH2:19][CH2:18][N:3]2[C:4]3[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 57800211HCID 57800211, compound

Product 1

HCID 86620711HCID 86620711, compound

Procedure

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 5-[(2-bromoethyl)oxy]-2-chloropyridine: MS (ES) m/z 380 (M+1) and 382 (M+1, isotope).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-29f9fb9b76c44825a20840c4d5b7a976
Source dataset
uspto-grants-2014_03
Patent number
US08673948B2

Reaction notes

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