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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188666Generated: October 26, 2026

2-Chloroethyl methyl ether → 2-Methyl-1-[2-(methyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188666

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloroethyl methyl etherHCID 12316—
Reactant2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 53309346—
Product2-Methyl-1-[2-(methyloxy)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405277—

Reaction Steps

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 2-chloroethyl methyl ether: MS (ES) m/z 283 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-50e480b7a1b1454e9348ae03c0c26d57
Source noteuspto-grants-2014_03