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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188682Generated: October 26, 2026

4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole → 1-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188682

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-thiazoleHCID 610297—
Reactant2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404472—
Product1-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67403833—

Reaction Steps

Synthesized as described in Example 4 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 165A) and 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole: MS (ES) m/z 458 (M+1) and 460 (M+1, isotope).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-9b93d48067c94521a36e1e73e577d212
Source noteuspto-grants-2014_03