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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188683Generated: October 26, 2026

4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole → 2-Cyclopropyl-4-(trifluoromethyl)-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188683

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazoleHCID 2736625—
Reactant2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67404472—
Product2-Cyclopropyl-4-(trifluoromethyl)-1-({2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl)-1H-indole-5-carbonitrileHCID 86620717—

Reaction Steps

Synthesized as described in Example 4 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 165A) and 4-(chloromethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole: MS (ES) m/z 492 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-3912aa411e724a34a987d76702a9a0e8
Source noteuspto-grants-2014_03