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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188699Generated: November 2, 2026

5-(Trifluoromethyl)nicotinic acid → 2-Cyclopropyl-4-(trifluoromethyl)-1-({5-[5-(trifluoromethyl)-3-pyridinyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188699

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Trifluoromethyl)nicotinic acidHCID 10976305—
ReactantHCID 178509470HCID 178509470—
Product2-Cyclopropyl-4-(trifluoromethyl)-1-({5-[5-(trifluoromethyl)-3-pyridinyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrileHCID 86620727—

Reaction Steps

Synthesized as described in Example 72 from 2-[5-cyano-2-cyclopropyl-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide (Example 364B) and 5-(trifluoromethyl)-3-pyridinecarboxylic acid: MS (ES) m/z 478 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08673948B2
Source datasetuspto-grants-2014_03
ORD IDord-3a3c36a17de84933b5d7218b62951cfd
Source noteuspto-grants-2014_03