Dimethyl Sulfoxide → HCID 46701100, compound

Participants

Reaction Steps

8-(2,6-difluorobenzyl)-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (23 mg, 0.05 mmol, Example 61) was treated with NaSMe (5 mg, 0.06 mmol) in DMSO (0.2 mL) at 100° C. for 2 h. The reaction mixture was diluted with water, the precipitated product was filtered off, then purified by silica gel column chromatography using dichloromethane:methanol (95:5) to give 8-(2-fluoro-6-(methylthio)benzyl)-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (22 mg, Y=90%). ESMS m/z 491 (M+H)+.

Provenance & Evidence