Dimethylformamide → HCID 66726142, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(benzyloxy)-4-fluoro-1-nitrobenzene (16.8 g), 4-methylthiophenol (10.0 g), potassium carbonate (14.1 g) and N,N-dimethylformamide (150 mL) was stirred at 80° C. for 2 hr. The reaction mixture was concentrated under reduced pressure, water was added, and the mixture was subjected to extraction with ethyl acetate. The organic layer was washed successively with water and saturated brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The obtained solid was washed with diethyl ether to give the title compound (23.2 g, yield 93%) as a pale-yellow solid. The pale-yellow solid was recrystallized from ethanol to give pale-yellow crystals melting point 81-82° C.

Provenance & Evidence