Water → HCID 46941671, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(benzyloxy)-4-[4-(methylsulfonyl)phenoxy]-1-nitrobenzene (11.0 g), iron powder (7.6 g), calcium chloride (0.3 g), water (30 mL) and ethanol (120 mL) was stirred at 80° C. for 2 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated. Water was added to the residue, and the mixture was subjected to extraction with ethyl acetate. The organic layer was washed successively with water and saturated brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The obtained crude product was crystallized from toluene, and the obtained solid was washed with diethyl ether to give the title compound (9.3 g, yield 92%) as pale-brown crystals. MS 370 (MH+).

Provenance & Evidence