Ethyl 7-(benzyloxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate → Ethyl 7-hydroxy-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate

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Reaction Steps

Ethyl 7-(benzyloxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate (0.40 g) was dissolved in a mixed solvent of tetrahydrofuran (5 mL)-ethanol (5 mL), 10% palladium-carbon (50% containing water, 0.80 g) was added, and the mixture was stirred at room temperature for 4 hr under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was crystallized from diethyl ether, and the obtained solid was washed with a mixed solvent of diethyl ether-hexane to give the title compound (0.31 g, yield 96%) as a pale-yellow solid. The pale-yellow solid was recrystallized from ethanol-hexane to give pale-yellow crystals. melting point 197-198° C.

Provenance & Evidence