HCID 66897681, compound → HCID 66897529, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 7-(1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate (1.87 g) was dissolved in a mixture of tetrahydrofuran (20 mL) and ethanol (20 mL), and 1M aqueous sodium hydroxide solution (9 mL) was added to the mixture. After stirring at 60° C. for 1 h, the mixture was concentrated under reduced pressure and the residue was dissolved in water. The mixture was cooled to 0° C. and 1M hydrochloric acid (10 mL) was added. The resulting white suspension was filtered to collect a white precipitate. The precipitate was dissolved in ethyl acetate and the solution was dried over magnesium sulfate, filtered, and concentrated to give the title compound (1.81 g, 100%) as a white amorphous solid. MS 390 (MH+).

Provenance & Evidence