Lawesson's reagent → HCID 86652838, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-(1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxamide (700 mg) in tetrahydrofuran (40 mL) was added Lawesson's reagent (729 mg) and the mixture was stirred at 60° C. for 40 min. The mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=5/95 to 50/50, volume ratio) to give the title compound (857 mg, 100%) as a yellow amorphous solid. MS 405 (MH+).

Provenance & Evidence